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Delfex 120mg Tablet 1 Strip
- Delfex 120 mg Tablet is a second-generation antihistamine used to alleviate allergic symptoms such as itching, swelling, and skin rashes. It works by blocking the action of histamine, a chemical released by the body during allergic reactions. Compared to older antihistamines, Delfex is less likely to cause drowsiness.
- Avoid fruit juices like apple, orange, or grapefruit while taking Delfex, as they may reduce the effectiveness of the medication.
- Nausea may occur as a side effect. Eating light, non-spicy meals may help alleviate this.
- Antacids can interfere with Delfex absorption. Do not take antacids within 30 minutes before or after taking this medicine.
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✅ Description:
Fexofenadine, the active component of Delfex, is a selective histamine H1 receptor inverse agonist. Upon exposure to allergens, immune cells such as mast cells and basophils release histamine, triggering allergic symptoms like a runny nose, itching, sneezing, and watery eyes.
Fexofenadine stabilizes the inactive form of the H1 receptor, thereby preventing activation and histamine-induced inflammatory responses. It exhibits high specificity for peripheral H1 receptors without interacting with dopamine, serotonin, cholinergic, or adrenergic receptors. Notably, it does not cross the blood-brain barrier, minimizing the risk of central nervous system side effects such as sedation.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Uses of Delfex 120
1. Allergic Rhinitis:
Delfex is indicated for managing both seasonal and perennial allergic rhinitis in adults and adolescents aged 12 years and above. It effectively alleviates symptoms like sneezing, nasal discharge, itchy or watery eyes, and irritation of the nose, palate, and throat. It also contributes to improved daily functioning and quality of life.
2. Chronic Idiopathic Urticaria:
Delfex is also indicated for treating chronic idiopathic urticaria in adults and adolescents 12 years and older. It helps reduce the number and severity of hives and relieves itching, thereby enhancing patient comfort and work productivity.
✔️ Side Effects of Delfex 120
Common (≥1/100 to <1/10):
- Headache, drowsiness, dizziness, nausea
Uncommon (≥1/1,000 to <1/100):
- Fatigue
Post-marketing (frequency unknown):
- Immune: Hypersensitivity, angioedema, anaphylaxis
- Psychiatric: Insomnia, nervousness, vivid dreams
- Cardiac: Palpitations, tachycardia
- GI: Diarrhea
- Skin: Rash, urticaria, pruritus
✔️ Dosage & Administration of Delfex 120
Allergic Rhinitis
Adults & Children ≥12 years:
60 mg twice daily OR
120 mg once daily OR
180 mg once daily
Renal impairment: 60 mg once daily
Children 6–11 years:
30 mg twice daily OR 60 mg once daily
Renal impairment: 30 mg once daily
Children 2–11 years (Suspension):
30 mg (5 ml) twice daily
Renal impairment: 30 mg (5 ml) once daily
Chronic Idiopathic Urticaria
Adults & Children ≥12 years:
60 mg twice daily OR
120 mg once daily OR
180 mg once daily
Renal impairment: 60 mg once daily
Children 6–11 years:
30 mg twice daily OR 60 mg once daily
Renal impairment: 30 mg once daily
Children 2–11 years (Suspension):
30 mg (5 ml) twice daily
Renal impairment: 30 mg (5 ml) once daily
Children 6 months–<2 years (Suspension):
15 mg (2.5 ml) twice daily
Renal impairment: 15 mg (2.5 ml) once daily
Renal impairment: Reduced clearance; dose adjustment necessary.
Hepatic impairment: No significant alteration in pharmacokinetics.
Elderly: Increased drug exposure; monitor accordingly.
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✔️ Overdose of Delfex 120
- Reported symptoms: Dizziness, fatigue, drowsiness, dry mouth.
- No serious outcomes with doses up to 800 mg.
- No specific antidote; manage with supportive care.
- Hemodialysis is ineffective in removing the drug.
✔️ Drug Interactions
- Does not undergo liver metabolism, minimizing hepatic interaction risk.
- Erythromycin/Ketoconazole: Can increase fexofenadine plasma levels 2–3 fold, without clinical significance.
- Antacids (aluminum/magnesium): Reduce absorption. Space dosing by at least 2 hours.
- No significant interaction with omeprazole was observed.
✔️ Contraindications
Hypersensitivity to fexofenadine or any formulation component.
✔️ Pregnancy & Lactation
- Pregnancy: Use only if clearly necessary; insufficient human data available.
- Lactation: Not recommended due to potential transfer via breast milk.
- Fertility: No human data; animal studies showed no adverse effect.
✔️ Precautions & Warnings
- Use cautiously in the elderly or patients with renal impairment.
- Caution in cardiovascular patients: Antihistamines have been associated with palpitations and tachycardia.
- Driving/Operating Machinery: Unlikely to impair abilities, but individual response should be assessed.
✔️ Storage:
- Store in a dry, cool place away from heat and light.
- Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
